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She was raised in the Detroit suburbs of Pontiac and Avon Township (now Rochester Hills).
Months before her mother died of breast cancer at age 30 on December 1, 1963, Madonna noticed changes in her behavior and personality, although she did not understand the reason.
She followed it with a series of commercially and critically successful albums, including the Grammy Award winners Ray of Light (1998) and Confessions on a Dance Floor (2005).
Throughout her career, Madonna has written and produced most of her songs, with many of them reaching number one on the record charts, including "Like a Virgin", "Papa Don't Preach", "Like a Prayer", "Vogue", "Take a Bow", "Frozen", "Music", "Hung Up", and "4 Minutes".
Her mother was at a loss to explain her medical condition, and often began to cry when Madonna questioned her about it.