Non sedating antihistamine comparison
This suggests that H2 blockers (commonly used to reduce stomach acid), at least those that cross into the brain, may have a central vestibular suppressant effect.
To our knowledge, this potential use has never been exploited.
Smith reported that 94% of the ENT surgeons in the United Kingdom prescribe betahistine to their Meniere's patients (Smith et al, 2005) This drug (brand name Serc, chemical name betahistine), is advocated as a vestibular suppressant mainly for Meniere's disease.
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H1 and H2 are post-synaptic receptors and H3 is a pre-synaptic receptor.
H4 is exitatory to the peripheral vestibular neurons (Wersinger et al, 2013).
All four types of histamine receptors are found in the mouse ear as well (Takumida et al, 2016) Betahistine is a potent H3 receptor antagonist. Stimulation of the H3 receptor reduces histamine release, so antagonism of H3 increases histamine release.
H3 receptors control the synthesis and release of histamine via a Gs protein (de Waele et al, 1995).
This is just one example of the large array of confusing literature about this drug. Many newer allergy medications are selective peripheral H1 blockers, and many older allergy medications, including those used for dizziness such as dramamine, are peripheral and central H1 blockers.